PAWR

Across TCGA patient cohorts, PAWR mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAWR-associated genes across cancer lineages are ATM, EGFR_pY1068, and A-Raf_pS299. Each is linked with PAWR in more than 1 cancer types. Because this analysis shows association rather than direction, both PAWR-to-partner and partner-to-PAWR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PAWR-low versus PAWR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAWR→partner) and Y-score (partner→PAWR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.586	-3.321	.013	.010	3	2
UCEC	EGFR_pY1068 →	-0.327	-3.321	.013	.010	3	1
UCEC	A-Raf_pS299 →	-0.158	-3.000	.011	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.255	-3.308	.003	.010	3	1
UCEC	MEK1 →	+0.502	+3.321	.008	.010	3	1
UCEC	Shc_pY317 →	-0.225	-3.000	.004	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by PAWR expression — UCEC

Explore this box plot interactively →