PAWR

Across TCGA pan-cancer cohorts, PAWR RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PAWR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PAWR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PAWR is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where PAWR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAWR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.038	<.001	12	view →
KIRC	Male	III,IV	−0.887	<.001	11	view →
STAD	All	II,III,IV	+0.891	<.001	10	view →
KICH	Female	All	−1.237	<.001	7	view →
UCEC	All	All	−0.902	<.001	6	view →
LUSC	Male	II,III,IV	+0.893	<.001	6	view →
LIHC	All	All	+0.515	<.001	6	view →
CHOL	All	All	+1.974	<.001	5	view →
BRCA	All	II,III,IV	+0.354	.004	4	view →
ESCA	All	II,III,IV	+1.119	.003	3	view →
LUAD	Male	All	+0.546	.003	2	view →
COAD	Male	All	+0.354	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PAWR–HNSC

Open the HNSC breakdown →