PAWR

Across TCGA pan-cancer cohorts, PAWR RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PAWR data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PAWR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAWR expression acts as an unfavorable survival marker, although some lineages such as SCLC and BLCA show a favorable association.

UVM, HNSC, and MESO are the cancer types where PAWR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.217	0.854	<.001	53	view →
HNSC	OS	Median	III,IV	0.665	0.784	<.001	47	view →
MESO	DFS	Median	II,III,IV	0.313	0.495	.007	46	view →
LUAD	OS	Tertile	All	0.180	0.517	<.001	36	view →
LGG	OS	Median	All	0.846	0.941	<.001	34	view →
KIRP	OS	Median	All	0.593	0.920	.016	27	view →
SCLC	DFS	Quartile	II,III,IV	0.575	0.226	.015	17	view →
PAAD	OS	Tertile	All	0.363	0.614	.006	16	view →
BLCA	DFS	Quartile	III,IV	0.452	0.224	.007	14	view →
READ	OS	Quartile	IV	1.000	0.466	.006	13	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PAWR–UVM (DFS)

Open the UVM breakdown →