PAWR

Across TCGA cell cohorts, PAWR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PAWR-associated GO terms across cancer lineages are Stress granule assembly, Long-chain fatty acid metabolic process, and Vacuolar transport. Each is linked with PAWR in more than 11 cancer types. Because this analysis shows association rather than direction, both PAWR-to-partner and partner-to-PAWR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stress granule assembly grouped by PAWR-low versus PAWR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAWR→partner) and Y-score (partner→PAWR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Stress granule assembly →	+0.114	+0.755	.001	<.001	2	12
BONE	Long-chain fatty acid metabolic process →	-0.084	-1.596	.001	.006	2	11
BONE	Vacuolar transport →	+0.050	+1.408	<.001	.003	3	10
OVARY	Post-transcriptional gene silencing →	+0.110	+0.977	<.001	<.001	3	10
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.098	+2.316	<.001	<.001	2	11
BONE	Signal transduction in response to DNA damage →	+0.079	+1.951	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Stress granule assembly by PAWR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →