Across TCGA patient cohorts, PARPBP mutation is significantly associated with the RNA expression of many other genes, with 3,292 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARPBP-associated genes across cancer lineages are PSMB3P2, RNU6ATAC30P, and RNU2-35P. Each is linked with PARPBP in more than 2 cancer types. Because this analysis shows association rather than direction, both PARPBP-to-partner and partner-to-PARPBP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARPBP→partner) and Y-score (partner→PARPBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PSMB3P2 →	+0.091	+2.997	<.001	.009	3	3
HNSC	RNU6ATAC30P →	+0.534	+4.245	<.001	.008	3	2
BRCA	RNU2-35P →	+0.473	+4.448	<.001	.001	3	2
BRCA	RN7SL602P →	+0.116	+3.947	<.001	.003	3	2
STAD	MIR5580 →	+0.747	+4.532	<.001	.001	3	2
UCEC	TMEM107 →	+0.433	+1.595	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,292 associations by consensus.

Exploration

PARPBP survival (RNA) · tumor vs normal (RNA) · all PARPBP data types