PARP9

Across TCGA patient cohorts, PARP9 mutation is significantly associated with the RNA expression of many other genes, with 2,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP9-associated genes across cancer lineages are ANKMY2, UBR7, and LARP1B. Each is linked with PARP9 in more than 3 cancer types. Because this analysis shows association rather than direction, both PARP9-to-partner and partner-to-PARP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKMY2 grouped by PARP9-low versus PARP9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP9→partner) and Y-score (partner→PARP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANKMY2 →	+0.409	+2.545	<.001	<.001	3	3
UCEC	UBR7 →	+0.321	+2.021	.007	.001	3	3
UCEC	LARP1B →	+0.406	+1.638	.001	.001	3	3
UCEC	MIR3912 →	+0.198	+2.053	<.001	<.001	3	3
UCEC	UQCRH →	+0.664	+1.606	.004	.001	3	3
UCEC	ZBTB8OS →	+0.239	+1.410	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,443 associations by consensus.

ANKMY2 by PARP9 expression — UCEC

Explore this box plot interactively →