PARP9

Across TCGA cell cohorts, PARP9 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,935 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PARP9-associated GO terms across cancer lineages are Negative regulation of IP-10 production, Positive regulation of interleukin-4-mediated signaling pathway, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with PARP9 in more than 17 cancer types. Because this analysis shows association rather than direction, both PARP9-to-partner and partner-to-PARP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of IP-10 production grouped by PARP9-low versus PARP9-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP9→partner) and Y-score (partner→PARP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of IP-10 production →	+1.052	+1.654	.001	<.001	3	18
LUNG_NSCLC_LUSC	Positive regulation of interleukin-4-mediated signaling pathway →	+1.559	+2.239	<.001	<.001	3	18
PANCREAS	Cytoplasmic pattern recognition receptor signaling pathway →	+0.085	+1.079	<.001	.002	3	18
BREAST	Negative regulation of viral genome replication →	+0.239	+1.725	<.001	<.001	3	17
BONE	Antigen processing and presentation of exogenous peptide antigen via MHC class Ib →	+0.261	+1.966	<.001	<.001	3	17
OESOPHAGUS	Positive regulation of response to type II interferon →	+1.628	+1.932	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,935 associations by consensus.

Negative regulation of IP-10 production by PARP9 expression — BREAST

Explore this box plot interactively →