PARP6

Across TCGA cell cohorts, PARP6 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP6-associated genes across cancer lineages are OR9A2, VN1R2, and OR14A16. Each is linked with PARP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP6-to-partner and partner-to-PARP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A2 grouped by PARP6-low versus PARP6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP6→partner) and Y-score (partner→PARP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR9A2 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	VN1R2 →	+0.006	+5.643	.003	.002	3	1
BLOOD_Lymphoma	OR14A16 →	+0.023	+5.643	<.001	.002	3	1
BLOOD_Leukemia	EPPIN →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	USP17L13 →	+0.006	+5.969	<.001	.001	3	1
BLOOD_Leukemia	USP17L17 →	+0.006	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

OR9A2 by PARP6 expression — BLOOD_Lymphoma

Explore this box plot interactively →