PARP6

Across TCGA pan-cancer cohorts, PARP6 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PARP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PARP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PARP6 is over-expressed in tumor, although a few such as PRAD and KICH show the opposite, repressed pattern.

KIRC, HNSC, and UCEC are the cancer types where PARP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.036	<.001	11	view →
HNSC	All	III,IV	+0.807	<.001	10	view →
UCEC	All	III,IV	+1.032	.003	6	view →
COAD	All	All	+0.462	.004	4	view →
LUSC	All	All	+0.272	.005	4	view →
CHOL	Female	All	+2.659	<.001	3	view →
READ	All	All	+0.661	.004	2	view →
LUAD	Male	III,IV	+0.641	.021	2	view →
PRAD	All	All	−0.602	<.001	2	view →
LIHC	Female	All	+0.590	.018	2	view →
KICH	All	All	−0.469	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PARP6–KIRC

Open the KIRC breakdown →