PARK7

Across TCGA patient cohorts, PARK7 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARK7-associated genes across cancer lineages are ELAVL4-AS1, RN7SL415P, and RN7SL447P. Each is linked with PARK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARK7-to-partner and partner-to-PARK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELAVL4-AS1 grouped by PARK7-low versus PARK7-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARK7→partner) and Y-score (partner→PARK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ELAVL4-AS1 →	+0.051	+5.103	.006	.008	3	1
CESC	RN7SL415P →	+0.203	+5.812	<.001	.003	3	1
CESC	RN7SL447P →	+0.230	+5.201	<.001	.007	3	1
CESC	RNU6-389P →	+0.340	+5.103	.004	.008	3	1
CESC	IGHVIV-44-1 →	+0.218	+5.201	<.001	.007	3	1
CESC	CYCSP22 →	+0.160	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ELAVL4-AS1 by PARK7 expression — CESC

Explore this box plot interactively →