PARK7

Across TCGA pan-cancer cohorts, PARK7 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PARK7 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher PARK7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PARK7 expression acts as an unfavorable survival marker, although some lineages such as CHOL and THCA show a favorable association.

KICH, HNSC, and ACC are the cancer types where PARK7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.490	1.000	.002	100	view →
HNSC	DFS	Median	II,III,IV	0.616	0.747	<.001	91	view →
ACC	DFS	Quartile	All	0.165	0.855	<.001	69	view →
UVM	OS	Median	All	0.390	0.890	<.001	63	view →
LAML	DFS	Median	All	0.438	0.692	<.001	36	view →
DLBC	DFS	Median	II,III,IV	0.477	1.000	.005	34	view →
CHOL	DFS	Tertile	All	0.780	0.106	.001	34	view →
THCA	DFS	Median	All	0.899	0.760	<.001	32	view →
ESCA	OS	Median	III,IV	0.400	0.696	.002	31	view →
UCEC	DFS	Median	IV	0.201	0.654	.001	30	view →
LIHC	DFS	Median	II,III,IV	0.537	0.298	<.001	30	view →
UCS	DFS	Tertile	IV	0.361	0.932	.024	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PARK7–KICH (DFS)

Open the KICH breakdown →