PAQR3

Across TCGA patient cohorts, PAQR3 mutation is significantly associated with the RNA expression of many other genes, with 1,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAQR3-associated genes across cancer lineages are ACTR3BP3, RAB28P2, and RNU6-351P. Each is linked with PAQR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAQR3-to-partner and partner-to-PAQR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR3BP3 grouped by PAQR3-low versus PAQR3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAQR3→partner) and Y-score (partner→PAQR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ACTR3BP3 →	+0.044	+7.930	<.001	.008	3	2
UCEC	RAB28P2 →	+0.034	+2.847	.009	.008	3	2
STAD	RNU6-351P →	+0.352	+5.463	<.001	.005	3	2
BLCA	RN7SL863P →	+0.134	+7.640	<.001	.009	3	2
SKCM	OR4D7P →	+0.047	+5.224	.003	.007	3	2
LUAD	RNU6-475P →	+0.578	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

ACTR3BP3 by PAQR3 expression — LUAD

Explore this box plot interactively →