PAQR3

Across TCGA pan-cancer cohorts, PAQR3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PAQR3 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PAQR3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PAQR3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and UCEC show a favorable association.

THCA, KICH, and UVM are the cancer types where PAQR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	0.899	0.994	.005	58	view →
KICH	DFS	Tertile	All	0.651	1.000	.001	56	view →
UVM	DFS	Quartile	III,IV	0.222	0.914	.001	38	view →
MESO	OS	Median	All	0.290	0.482	.007	32	view →
LGG	OS	Tertile	All	0.848	0.944	<.001	21	view →
LUSC	DFS	Median	II,III,IV	0.669	0.505	.013	21	view →
UCEC	OS	Tertile	III,IV	0.902	0.764	.003	20	view →
BRCA	DFS	Median	III,IV	0.926	0.822	.014	19	view →
LIHC	DFS	Median	All	0.488	0.597	.006	19	view →
CESC	DFS	Median	III,IV	0.263	0.571	.011	18	view →
PAAD	OS	Median	All	0.527	0.733	.009	15	view →
ACC	DFS	Quartile	III,IV	0.578	0.097	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PAQR3–THCA (OS)

Open the THCA breakdown →