PANX1

Across TCGA patient cohorts, PANX1 mutation is significantly associated with the RNA expression of many other genes, with 2,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PANX1-associated genes across cancer lineages are MIR6803, LINC02130, and RNU6-918P. Each is linked with PANX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PANX1-to-partner and partner-to-PANX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by PANX1-low versus PANX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PANX1→partner) and Y-score (partner→PANX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.161	+4.571	<.001	.002	3	3
LUAD	LINC02130 →	+0.336	+4.243	<.001	.008	3	2
UCEC	RNU6-918P →	+0.315	+2.720	<.001	.004	3	2
LUSC	MTND2P20 →	+0.080	+3.249	.004	.005	3	2
SKCM	MIR4511 →	+0.451	+4.454	<.001	.002	3	2
SKCM	RN7SL831P →	+0.246	+5.634	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,294 associations by consensus.

MIR6803 by PANX1 expression — UCEC

Explore this box plot interactively →