PAM

Across TCGA patient cohorts, PAM protein abundance is significantly associated with the RNA expression of many other genes, with 10,594 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PAM-associated genes across cancer lineages are NALCN, DAAM2, and SCG5. Each is linked with PAM in more than 4 cancer types. Because this analysis shows association rather than direction, both PAM-to-partner and partner-to-PAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAM versus NALCN in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAM→partner) and Y-score (partner→PAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NALCN →	+0.994	+0.470	<.001	<.001	3	5
GBM	DAAM2 →	+0.815	+0.325	.005	.003	3	5
PDAC	SCG5 →	+1.131	+0.450	<.001	<.001	3	5
GBM	DOK6 →	+0.652	+0.292	<.001	.002	3	5
BRCA	COMP →	+1.793	+0.420	<.001	.001	3	4
CCRCC	GLRB →	+1.018	+0.311	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,594 associations by consensus.

PAM vs NALCN — GBM

Explore this scatter interactively →