PAM

Across TCGA pan-cancer cohorts, PAM RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PAM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PAM RNA is repressed in tumor relative to normal tissue. In most cancer types PAM is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where PAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.915	<.001	9	view →
KIRC	Female	All	+0.807	<.001	9	view →
THCA	All	II,III,IV	+0.506	<.001	9	view →
BLCA	Male	All	−1.585	<.001	8	view →
HNSC	Female	III,IV	+1.550	<.001	8	view →
LUSC	Female	All	−0.778	<.001	7	view →
BRCA	All	III,IV	−0.788	<.001	6	view →
LUAD	All	All	+0.405	<.001	6	view →
LIHC	Female	All	+0.947	<.001	5	view →
CHOL	All	All	+1.753	<.001	3	view →
KIRP	Male	All	−0.296	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PAM–KICH

Open the KICH breakdown →