PADI4

Across TCGA cell cohorts, PADI4 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PADI4-associated genes across cancer lineages are OR5H8, GUCA2A, and TBC1D3H. Each is linked with PADI4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI4-to-partner and partner-to-PADI4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5H8 grouped by PADI4-low versus PADI4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI4→partner) and Y-score (partner→PADI4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR5H8 →	+0.026	+4.421	.001	.004	3	1
SKIN	GUCA2A →	+0.078	+4.273	<.001	.006	3	1
SKIN	TBC1D3H →	+0.677	+4.095	<.001	.009	3	1
BLOOD_Leukemia	NUDT10 →	+1.041	+3.977	<.001	<.001	3	1
BLOOD_Leukemia	CPXCR1 →	+0.057	+3.234	.001	.002	3	1
BLOOD_Leukemia	EDA →	+1.204	+3.470	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

OR5H8 by PADI4 expression — BREAST

Explore this box plot interactively →