P2RY8

Across TCGA patient cohorts, P2RY8 mutation is significantly associated with the RNA expression of many other genes, with 2,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY8-associated genes across cancer lineages are RNU6-1082P, PIAS4, and COMMD9. Each is linked with P2RY8 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY8-to-partner and partner-to-P2RY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1082P grouped by P2RY8-low versus P2RY8-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY8→partner) and Y-score (partner→P2RY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNU6-1082P →	+0.378	+3.321	.003	.007	3	3
UCEC	PIAS4 →	+0.320	+2.069	<.001	<.001	3	3
UCEC	COMMD9 →	+0.324	+1.562	<.001	.008	3	3
UCEC	SRSF4 →	+0.394	+2.378	<.001	<.001	3	3
UCEC	FKBP15 →	+0.328	+1.799	<.001	.001	3	3
UCEC	AOC2 →	+0.628	+2.592	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,019 associations by consensus.

RNU6-1082P by P2RY8 expression — GBM

Explore this box plot interactively →