P2RY8

Across TCGA pan-cancer cohorts, P2RY8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of P2RY8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where P2RY8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P2RY8 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where P2RY8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RY8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.105	<.001	12	view →
COAD	Female	III,IV	−1.414	<.001	10	view →
LIHC	All	II,III,IV	+1.289	<.001	8	view →
KICH	Male	II,III,IV	−0.943	<.001	8	view →
LUSC	Male	II,III,IV	−1.113	<.001	7	view →
UCEC	All	All	−0.835	<.001	6	view →
BLCA	All	All	−0.793	.012	6	view →
KIRP	All	II,III,IV	−0.774	.006	6	view →
THCA	Male	III,IV	−1.291	.006	3	view →
HNSC	Female	II,III,IV	+0.663	.016	3	view →
BRCA	Female	All	+0.212	.031	2	view →
CHOL	All	All	+1.231	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

P2RY8–KIRC

Open the KIRC breakdown →