P2RY8

Across TCGA patient cohorts, P2RY8 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY8-associated genes across cancer lineages are p62 Lck ligand, TFRC, and 14-3-3_beta. Each is linked with P2RY8 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY8-to-partner and partner-to-P2RY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by P2RY8-low versus P2RY8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY8→partner) and Y-score (partner→P2RY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.305	+2.700	.009	.005	3	3
UCEC	TFRC →	+0.514	+3.584	.007	.002	3	2
UCEC	14-3-3_beta →	-0.095	-2.432	.008	.018	3	1
UCEC	ERK2 →	+0.206	+3.700	.002	.001	3	1
UCEC	INPP4B →	-0.294	-2.700	.011	.005	3	1
UCEC	Ku80 →	+0.190	+1.884	.025	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p62 Lck ligand by P2RY8 expression — UCEC

Explore this box plot interactively →