P2RY8

Across TCGA cell cohorts, P2RY8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,961 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RY8-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, Cell division, and Nucleus organization. Each is linked with P2RY8 in more than 7 cancer types. Because this analysis shows association rather than direction, both P2RY8-to-partner and partner-to-P2RY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal transduction in response to DNA damage grouped by P2RY8-low versus P2RY8-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY8→partner) and Y-score (partner→P2RY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Signal transduction in response to DNA damage →	+0.076	+0.166	<.001	.001	3	8
BREAST	Cell division →	+0.074	+0.043	<.001	.005	3	7
OESOPHAGUS	Nucleus organization →	+0.065	+0.112	.001	.004	2	8
BREAST	Response to ionizing radiation →	+0.059	+0.050	<.001	.001	3	7
LARGE_INTESTINE	Response to transition metal nanoparticle →	-0.215	-0.096	<.001	.001	3	7
OESOPHAGUS	Positive regulation of chromosome organization →	+0.070	+0.129	.008	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,961 associations by consensus.

Signal transduction in response to DNA damage by P2RY8 expression — OESOPHAGUS

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