P2RY8

Across TCGA cell cohorts, P2RY8 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RY8-associated genes across cancer lineages are LRRC3C, ECE2, and ACOT12. Each is linked with P2RY8 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY8-to-partner and partner-to-P2RY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by P2RY8-low versus P2RY8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY8→partner) and Y-score (partner→P2RY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.258	+3.921	.001	.001	3	2
LARGE_INTESTINE	ECE2 →	+0.257	+3.376	<.001	.002	3	1
LARGE_INTESTINE	ACOT12 →	+0.029	+4.257	.002	<.001	3	1
LARGE_INTESTINE	FAM153B →	+0.538	+3.618	<.001	.003	3	1
LARGE_INTESTINE	NAT8B →	+0.721	+3.667	.002	.003	3	1
BLOOD_Lymphoma	SHD →	+0.538	+3.341	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

LRRC3C by P2RY8 expression — LARGE_INTESTINE

Explore this box plot interactively →