P2RY11

Across TCGA cell cohorts, P2RY11 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible P2RY11-associated genes across cancer lineages are VWC2L, CCT8L2, and IQCF6. Each is linked with P2RY11 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RY11-to-partner and partner-to-P2RY11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by P2RY11-low versus P2RY11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY11→partner) and Y-score (partner→P2RY11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.016	+4.339	<.001	.002	3	1
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	IQCF6 →	+0.571	+3.769	<.001	.008	3	1
BLOOD_Leukemia	KIR2DS4 →	+0.609	+4.234	<.001	.003	3	1
BLOOD_Leukemia	PRRT1B →	+0.022	+3.944	<.001	.006	3	1
LARGE_INTESTINE	SEMG2 →	+0.434	+2.878	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VWC2L by P2RY11 expression — BLOOD_Leukemia

Explore this box plot interactively →