P2RY10

Across TCGA patient cohorts, P2RY10 mutation is significantly associated with the RNA expression of many other genes, with 4,543 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RY10-associated genes across cancer lineages are RSPO4, TAF6, and G6PD. Each is linked with P2RY10 in more than 2 cancer types. Because this analysis shows association rather than direction, both P2RY10-to-partner and partner-to-P2RY10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPO4 grouped by P2RY10-low versus P2RY10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RY10→partner) and Y-score (partner→P2RY10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSPO4 →	-0.970	-1.989	.001	.001	3	3
SKCM	TAF6 →	+0.417	+3.647	<.001	.001	3	3
SKCM	G6PD →	+0.408	+2.321	.003	.005	3	3
SKCM	GAL →	-0.987	-2.980	.002	<.001	3	3
UCEC	TONSL →	+0.611	+2.949	<.001	<.001	3	3
UCEC	ZBTB17 →	+0.397	+2.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,543 associations by consensus.

RSPO4 by P2RY10 expression — UCEC

Explore this box plot interactively →