P2RY10

Across TCGA pan-cancer cohorts, P2RY10 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated P2RY10 data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher P2RY10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated P2RY10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where P2RY10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.769	0.620	<.001	138	view →
SKCM	OS	Median	All	0.418	0.262	<.001	123	view →
CESC	DFS	Quartile	All	0.870	0.628	<.001	72	view →
LUAD	DFS	Median	All	0.834	0.746	.002	52	view →
UVM	DFS	Quartile	II,III,IV	0.266	0.647	.009	48	view →
LGG	OS	Median	All	0.722	0.889	<.001	46	view →
BRCA	OS	Median	IV	0.914	0.509	.004	40	view →
UCS	DFS	Tertile	IV	0.855	0.250	.024	34	view →
OV	DFS	Tertile	All	0.422	0.333	.018	28	view →
LIHC	DFS	Median	III,IV	0.593	0.196	<.001	22	view →
COAD	DFS	Tertile	All	0.782	0.585	.008	20	view →
UCEC	OS	Tertile	III,IV	0.706	0.369	.006	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

P2RY10–HNSC (DFS)

Open the HNSC breakdown →