P2RX4

Across TCGA patient cohorts, P2RX4 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible P2RX4-associated genes across cancer lineages are MEP, Monocytes, and CD8+ Tcm. Each is linked with P2RX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX4-to-partner and partner-to-P2RX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP grouped by P2RX4-low versus P2RX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX4→partner) and Y-score (partner→P2RX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEP →	+0.033	+2.010	.008	.019	3	2
SKCM	Monocytes →	+0.016	+5.810	<.001	.026	3	1
LUSC	CD8+ Tcm →	+0.125	+2.729	<.001	.045	3	1
UCEC	Endothelial cells →	-0.042	-3.451	.013	.005	3	1
UCEC	HSC →	+0.121	+2.010	.013	.019	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEP by P2RX4 expression — UCEC

Explore this box plot interactively →