P2RX4

Across TCGA pan-cancer cohorts, P2RX4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of P2RX4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where P2RX4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types P2RX4 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where P2RX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in P2RX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.282	<.001	12	view →
COAD	Female	II,III,IV	−1.028	<.001	10	view →
HNSC	All	III,IV	+0.851	<.001	10	view →
KIRP	Male	II,III,IV	+1.095	<.001	9	view →
BLCA	All	All	+0.627	.014	8	view →
LIHC	Female	II,III,IV	+1.290	<.001	7	view →
STAD	All	II,III,IV	+0.911	<.001	6	view →
READ	All	All	−0.895	.011	6	view →
BRCA	All	III,IV	+0.793	<.001	6	view →
KICH	All	All	−0.491	.001	5	view →
CHOL	All	All	+1.965	<.001	3	view →
THCA	Female	All	+0.219	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

P2RX4–KIRC

Open the KIRC breakdown →