P2RX4

Across TCGA pan-cancer cohorts, P2RX4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated P2RX4 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher P2RX4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated P2RX4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BRCA show a favorable association.

UVM, UCEC, and MESO are the cancer types where P2RX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.389	0.975	<.001	148	view →
UCEC	DFS	Median	All	0.790	0.524	<.001	102	view →
MESO	OS	Median	All	0.279	0.504	.001	89	view →
BRCA	OS	Median	III,IV	0.908	0.752	<.001	85	view →
LIHC	DFS	Tertile	All	0.414	0.619	<.001	83	view →
KIRC	DFS	Tertile	All	0.740	0.492	.004	58	view →
LGG	OS	Median	All	0.361	0.533	<.001	54	view →
ACC	DFS	Tertile	All	0.224	0.830	.001	48	view →
LUAD	DFS	Tertile	IV	0.783	0.333	.010	30	view →
LUSC	OS	Median	II,III,IV	0.304	0.524	<.001	28	view →
ESCA	OS	Median	All	0.466	1.000	.016	21	view →
SCLC	DFS	Median	All	0.739	0.505	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

P2RX4–UVM (OS)

Open the UVM breakdown →