P2RX4

Across TCGA cell cohorts, P2RX4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible P2RX4-associated genes across cancer lineages are C9orf92, KIR2DS4, and CLDN17. Each is linked with P2RX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both P2RX4-to-partner and partner-to-P2RX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by P2RX4-low versus P2RX4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (P2RX4→partner) and Y-score (partner→P2RX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C9orf92 →	+0.456	+4.736	<.001	.009	3	1
SKIN	KIR2DS4 →	+0.009	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	CLDN17 →	+0.018	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.030	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.049	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.132	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C9orf92 by P2RX4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →