OVOL1

Across TCGA patient cohorts, OVOL1 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible OVOL1-associated genes across cancer lineages are HMGB1P50, RPL37P4, and OR51B2. Each is linked with OVOL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OVOL1-to-partner and partner-to-OVOL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P50 grouped by OVOL1-low versus OVOL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OVOL1→partner) and Y-score (partner→OVOL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGB1P50 →	+0.173	+2.735	.008	.006	3	2
COAD	RPL37P4 →	+0.584	+4.754	<.001	.003	3	2
COAD	OR51B2 →	+0.141	+6.409	<.001	<.001	3	2
UCEC	EIF3JP1 →	+0.319	+3.427	<.001	<.001	3	2
HNSC	OR8B4 →	+0.039	+7.954	<.001	.008	3	1
UCEC	RNA5SP414 →	+0.636	+2.933	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

HMGB1P50 by OVOL1 expression — UCEC

Explore this box plot interactively →