OVOL1

Across TCGA pan-cancer cohorts, OVOL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of OVOL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OVOL1 RNA is repressed in tumor relative to normal tissue. In most cancer types OVOL1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LUSC are the cancer types where OVOL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OVOL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−2.216	<.001	12	view →
KIRP	Male	III,IV	−2.373	<.001	11	view →
LUSC	All	III,IV	+2.965	<.001	9	view →
LUAD	Male	II,III,IV	+1.501	<.001	9	view →
KICH	All	All	−1.067	.001	7	view →
UCEC	All	All	+1.925	<.001	6	view →
BRCA	All	II,III,IV	+1.132	<.001	6	view →
STAD	All	All	+1.214	.019	5	view →
PAAD	All	All	+2.395	.005	4	view →
CHOL	All	All	+1.424	.004	4	view →
THCA	Female	All	−0.500	.001	4	view →
LIHC	All	All	+0.176	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

OVOL1–KIRC

Open the KIRC breakdown →