OVCH2

Across TCGA patient cohorts, OVCH2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OVCH2-associated genes across cancer lineages are C-Raf, eIF4E, and mTOR_pS2448. Each is linked with OVCH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OVCH2-to-partner and partner-to-OVCH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by OVCH2-low versus OVCH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OVCH2→partner) and Y-score (partner→OVCH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.141	+2.000	.012	.010	3	2
UCEC	eIF4E →	+0.215	+2.502	.009	.002	3	2
UCEC	mTOR_pS2448 →	-0.191	-3.308	.001	.009	3	2
UCEC	p62 Lck ligand →	+0.444	+2.000	<.001	.010	3	2
UCEC	Annexin-1 →	+0.596	+3.604	.003	.001	3	2
UCEC	ATM →	-0.660	-2.000	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

C-Raf by OVCH2 expression — UCEC

Explore this box plot interactively →