OVCH2

Across TCGA pan-cancer cohorts, OVCH2 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated OVCH2 data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher OVCH2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OVCH2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

UVM, BLCA, and UCS are the cancer types where OVCH2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	III,IV	0.376	0.828	<.001	76	view →
BLCA	DFS	Quartile	All	0.441	0.261	.006	64	view →
UCS	DFS	Median	II,III,IV	0.629	0.243	<.001	34	view →
READ	OS	Median	III,IV	0.752	0.290	.010	32	view →
KICH	DFS	Median	II,III,IV	1.000	0.654	.013	29	view →
KIRP	DFS	Quartile	All	0.568	0.819	.006	29	view →
COAD	OS	Median	IV	0.244	0.696	.002	23	view →
SKCM	DFS	Median	All	0.820	0.687	.005	18	view →
ACC	OS	Tertile	III,IV	0.167	0.524	.022	10	view →
STAD	OS	Median	IV	0.564	0.192	.004	9	view →
LUAD	OS	Median	All	0.768	0.637	.010	9	view →
CESC	DFS	Tertile	III,IV	0.273	0.708	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

OVCH2–UVM (DFS)

Open the UVM breakdown →