OTX2P1

Across TCGA pan-cancer cohorts, OTX2P1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated OTX2P1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher OTX2P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OTX2P1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

ACC, STAD, and UCS are the cancer types where OTX2P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.390	0.824	<.001	72	view →
STAD	OS	Tertile	II,III,IV	0.286	0.599	.006	63	view →
UCS	DFS	Tertile	All	0.336	0.539	.036	36	view →
BRCA	DFS	Tertile	IV	0.175	0.730	.005	36	view →
LIHC	DFS	Tertile	All	0.216	0.538	.012	30	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	27	view →
SARC	OS	Tertile	All	0.332	0.556	.007	26	view →
HNSC	OS	Tertile	All	0.510	0.331	.015	18	view →
LGG	OS	Tertile	All	0.574	0.808	.013	9	view →
KIRC	OS	Tertile	All	0.469	0.650	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

OTX2P1–ACC (OS)

Open the ACC breakdown →