OTX2P1

Across TCGA pan-cancer cohorts, OTX2P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of OTX2P1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OTX2P1 RNA is repressed in tumor relative to normal tissue. In most cancer types OTX2P1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA and LUSC are the cancer types where OTX2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTX2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.072	<.001	4	view →
LUSC	Male	All	−0.047	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

OTX2P1–THCA

Open the THCA breakdown →