OTOP1

Across TCGA cell cohorts, OTOP1 mutation is significantly associated with the RNA expression of many other genes, with 577 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OTOP1-associated genes across cancer lineages are CYP2A13, FAXC, and PPP1R2C. Each is linked with OTOP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOP1-to-partner and partner-to-OTOP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP2A13 grouped by OTOP1-low versus OTOP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOP1→partner) and Y-score (partner→OTOP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP2A13 →	+0.032	+5.044	<.001	.001	3	2
LARGE_INTESTINE	FAXC →	+1.203	+3.212	.002	.006	3	2
UPPER_AERODIGESTIVE_TRACT	PPP1R2C →	+0.025	+4.736	<.001	.009	3	1
CNS	OR11H6 →	+0.018	+4.321	<.001	.009	3	1
CNS	WFDC10A →	+0.166	+4.315	<.001	.006	3	1
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

CYP2A13 by OTOP1 expression — CNS

Explore this box plot interactively →