OTOP1

Across TCGA pan-cancer cohorts, OTOP1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OTOP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OTOP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTOP1 is over-expressed in tumor, although a few such as HNSC and STAD show the opposite, repressed pattern.

COAD, HNSC, and STAD are the cancer types where OTOP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTOP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	+0.220	.002	5	view →
HNSC	Female	All	−0.195	.023	4	view →
STAD	All	II,III,IV	−0.138	.006	3	view →
UCEC	All	IV	+0.215	.013	2	view →
LUSC	All	All	+0.118	.005	2	view →
LUAD	All	All	+0.025	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

OTOP1–COAD

Open the COAD breakdown →