ORMDL3

Across TCGA patient cohorts, ORMDL3 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORMDL3-associated genes across cancer lineages are MIR6846, CELF2-AS2, and RN7SL116P. Each is linked with ORMDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL3-to-partner and partner-to-ORMDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6846 grouped by ORMDL3-low versus ORMDL3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL3→partner) and Y-score (partner→ORMDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIR6846 →	+0.436	+5.678	<.001	.003	3	2
SKCM	CELF2-AS2 →	+0.048	+4.564	<.001	.001	3	1
SKCM	RN7SL116P →	+0.195	+4.199	<.001	.004	3	1
SKCM	CBX3P3 →	+0.120	+3.801	.001	.009	3	1
SKCM	MIR8075 →	+0.312	+5.900	<.001	<.001	3	1
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

MIR6846 by ORMDL3 expression — STAD

Explore this box plot interactively →