ORMDL3

Across TCGA pan-cancer cohorts, ORMDL3 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ORMDL3 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ORMDL3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ORMDL3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SCLC show a favorable association.

LUAD, SCLC, and BLCA are the cancer types where ORMDL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.839	0.742	<.001	78	view →
SCLC	DFS	Median	All	0.763	0.470	<.001	70	view →
BLCA	OS	Median	All	0.554	0.341	<.001	60	view →
HNSC	OS	Median	All	0.615	0.790	.001	38	view →
LGG	DFS	Median	All	0.677	0.790	.001	35	view →
THCA	OS	Quartile	II,III,IV	1.000	0.758	.005	34	view →
SKCM	OS	Tertile	All	0.850	0.735	.001	28	view →
PAAD	OS	Median	II,III,IV	0.475	0.738	.002	20	view →
UCEC	DFS	Median	IV	0.870	0.507	.013	20	view →
UVM	DFS	Tertile	III,IV	0.340	0.856	.016	18	view →
ACC	DFS	Quartile	All	0.557	0.828	.020	16	view →
COAD	OS	Tertile	IV	0.704	0.340	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ORMDL3–LUAD (DFS)

Open the LUAD breakdown →