OR6B3

Across TCGA cell cohorts, OR6B3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR6B3-associated genes across cancer lineages are CELA2A, TSKS, and NAT8. Each is linked with OR6B3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR6B3-to-partner and partner-to-OR6B3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2A grouped by OR6B3-low versus OR6B3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR6B3→partner) and Y-score (partner→OR6B3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CELA2A →	+0.056	+4.684	<.001	.002	3	1
LARGE_INTESTINE	TSKS →	+0.169	+3.333	.008	.009	3	1
LARGE_INTESTINE	NAT8 →	+0.567	+3.443	.003	.009	3	1
LARGE_INTESTINE	C14orf180 →	+0.144	+3.155	<.001	.008	3	1
LARGE_INTESTINE	KRTAP10-3 →	+0.041	+4.505	<.001	<.001	3	1
LARGE_INTESTINE	CLEC17A →	+0.028	+3.039	.002	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CELA2A by OR6B3 expression — SKIN

Explore this box plot interactively →