OR6B3

Across TCGA pan-cancer cohorts, OR6B3 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated OR6B3 data layer compared with 5 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher OR6B3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OR6B3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

DLBC, ACC, and LIHC are the cancer types where OR6B3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	52	view →
ACC	OS	Tertile	All	0.555	0.888	.002	45	view →
LIHC	OS	Tertile	III,IV	0.084	0.626	<.001	45	view →
ESCA	DFS	Tertile	All	0.372	0.568	.006	36	view →
BRCA	OS	Quartile	All	0.984	0.956	.009	28	view →
UCS	DFS	Tertile	IV	0.290	0.813	.003	24	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
SKCM	OS	Tertile	II,III,IV	1.000	0.818	.016	9	view →
PCPG	DFS	Tertile	All	0.070	0.936	<.001	9	view →
UVM	OS	Tertile	II,III,IV	1.000	0.542	.037	6	view →
HNSC	DFS	Tertile	All	0.693	0.587	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

OR6B3–DLBC (OS)

Open the DLBC breakdown →