OR52E4

Across TCGA patient cohorts, OR52E4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR52E4-associated genes across cancer lineages are Rb, ERK2, and ACC_pS79. Each is linked with OR52E4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52E4-to-partner and partner-to-OR52E4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rb grouped by OR52E4-low versus OR52E4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52E4→partner) and Y-score (partner→OR52E4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rb →	+0.132	+2.484	.037	.010	3	2
SKCM	ERK2 →	+0.252	+2.459	.002	.018	3	1
SKCM	ACC_pS79 →	+0.248	+1.906	.032	.016	3	1
SKCM	GSK-3_pS9 →	+0.385	+2.321	.032	.033	3	1
SKCM	Rab25 →	-0.246	-3.087	.014	<.001	3	1
SKCM	Rb_pS807_S811 →	+0.673	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rb by OR52E4 expression — SKCM

Explore this box plot interactively →