OR4F15

Across TCGA patient cohorts, OR4F15 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4F15-associated genes across cancer lineages are Shc_pY317, c-Met_pY1235, and EGFR_pY1068. Each is linked with OR4F15 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4F15-to-partner and partner-to-OR4F15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by OR4F15-low versus OR4F15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4F15→partner) and Y-score (partner→OR4F15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.147	-2.115	.027	.019	3	2
UCEC	c-Met_pY1235 →	+0.065	+2.115	.045	.019	3	2
UCEC	EGFR_pY1068 →	-0.237	-2.321	.030	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.575	.016	.010	3	1
UCEC	INPP4B →	-0.322	-3.169	.022	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Shc_pY317 by OR4F15 expression — UCEC

Explore this box plot interactively →