Across TCGA pan-cancer cohorts, OR4F15 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OR4F15’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OR4F15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OR4F15 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC, KIRP, and BRCA are the cancer types where OR4F15 tumor–normal differential expression is most reproducible.