OR4C11

Across TCGA patient cohorts, OR4C11 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OR4C11-associated genes across cancer lineages are Cyclin-E2, GAPDH, and EGFR_pY1068. Each is linked with OR4C11 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4C11-to-partner and partner-to-OR4C11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by OR4C11-low versus OR4C11-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4C11→partner) and Y-score (partner→OR4C11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-E2 →	+0.121	+3.331	.044	.005	3	1
SKCM	GAPDH →	+0.610	+2.459	.029	.020	3	1
UCEC	EGFR_pY1068 →	-0.341	-3.000	.009	.036	3	1
UCEC	Rad50 →	-0.380	-3.321	.002	.010	3	1
UCEC	Caspase-8 →	-0.286	-2.973	.029	.035	3	1
SKCM	p90 RSK →	+0.265	+3.000	.008	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Cyclin-E2 by OR4C11 expression — LUSC

Explore this box plot interactively →