OR2T8

Across TCGA patient cohorts, OR2T8 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible OR2T8-associated genes across cancer lineages are STAT5a, p62 Lck ligand, and p90 RSK. Each is linked with OR2T8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T8-to-partner and partner-to-OR2T8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by OR2T8-low versus OR2T8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T8→partner) and Y-score (partner→OR2T8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT5a →	+0.629	+3.169	.036	.019	3	2
SKCM	p62 Lck ligand →	+0.556	+2.820	.008	.035	3	1
UCEC	p90 RSK →	+0.236	+2.820	.044	.036	1	2
LUAD	c-Met →	+0.905	+2.824	.001	.036	1	1
SKCM	Akt_pT308 →	-0.565	-3.169	.037	.019	1	1
SKCM	AMPK_pT172 →	+0.485	+3.169	.006	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

STAT5a by OR2T8 expression — SKCM

Explore this box plot interactively →