OR2T8

Across TCGA pan-cancer cohorts, OR2T8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of OR2T8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OR2T8 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2T8 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where OR2T8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OR2T8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.742	<.001	7	view →
COAD	Female	All	−0.111	.001	4	view →
BRCA	All	All	+0.081	.027	3	view →
BRCA	All	IV	−0.285	.021	2	view →
PRAD	All	All	+0.137	.003	2	view →
LUAD	Male	All	−0.053	.009	2	view →
LUSC	Male	All	−0.076	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 6 lineages.

OR2T8–THCA

Open the THCA breakdown →