OR2T8

Across TCGA cell cohorts, OR2T8 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR2T8-associated genes across cancer lineages are TPPP2, FAM71C, and OR8B12. Each is linked with OR2T8 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T8-to-partner and partner-to-OR2T8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPPP2 grouped by OR2T8-low versus OR2T8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T8→partner) and Y-score (partner→OR2T8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TPPP2 →	+0.088	+5.217	<.001	<.001	3	1
SKIN	FAM71C →	+0.017	+4.095	<.001	.009	3	1
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	1
LUNG_SCLC	RD3L →	+0.018	+5.029	.004	.006	3	1
LUNG_NSCLC_LUAD	C1orf87 →	+0.206	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.020	+3.544	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TPPP2 by OR2T8 expression — SKIN

Explore this box plot interactively →