OR2T8

Across TCGA cell cohorts, OR2T8 mutation is significantly associated with the mutation status of many other genes, with 642 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OR2T8-associated genes across cancer lineages are ITIH5, GRIA3, and NF1. Each is linked with OR2T8 in more than 2 cancer types. Because this analysis shows association rather than direction, both OR2T8-to-partner and partner-to-OR2T8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITIH5 grouped by OR2T8-low versus OR2T8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T8→partner) and Y-score (partner→OR2T8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ITIH5 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	GRIA3 →	+3.263	+3.851	.005	.005	1	3
LUNG_NSCLC_LUAD	NF1 →	+2.678	+4.342	.002	.002	1	3
LUNG_NSCLC_LUAD	CNTNAP2 →	+2.540	+4.222	.003	.003	1	2
LUNG_NSCLC_LUAD	OR4K5 →	+3.000	+3.662	.007	.007	1	2
LUNG_NSCLC_LUAD	NCKAP5 →	+2.192	+3.896	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 642 associations by consensus.

ITIH5 by OR2T8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →