Across TCGA cell cohorts, OR2T4 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible OR2T4-associated genes across cancer lineages are RXFP2, FAM71C, and CCL24. Each is linked with OR2T4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR2T4-to-partner and partner-to-OR2T4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR2T4→partner) and Y-score (partner→OR2T4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RXFP2 →	+0.263	+4.044	<.001	.009	3	2
SKIN	FAM71C →	+0.010	+2.925	.003	.007	3	1
LUNG_SCLC	CCL24 →	+0.145	+4.269	<.001	.005	3	1
LUNG_SCLC	NEU2 →	+0.015	+4.643	<.001	.004	3	1
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	ACER1 →	+0.066	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

OR2T4 survival (RNA) · tumor vs normal (RNA) · all OR2T4 data types